Role of Panchamruta Rasa (Panchadasha) as a immunomodulator w.s.r. Rasayana : A Review

In Ayurveda, text immunity had been described by Chakrapani in terms of Vyadhikshamatva and it is termed as a state of equilibrium of Oja, Bala, Prakrit Kapha. The modulation of immune response by using Ayurvedic herbal medication as a possible therapeutic measure has now become a subject of scientific investigation. Immunomodulators can be defining as substance which can affect any function of the immune system including both innate and adaptive immunity. In Ayurveda, this concept of immunomodulation correlated with Rasayana. Rasayana acts in the body at three levels i.e. Rasa, Agni, Strotas. The present review is undertaken for screening minerals & herbs (ingredients) of Panchamruta Rasa (Panchadasha) to evaluate their immunomodulatory properties and establish the correlation between Rasayana and immunomodulatory effect. Critical review of minerals & herbs to show immunomodulatory property is compiled from various Ayurvedic texts as well as from multiple articles on the internet to justify their immunomodulatory property on the basis of data collected. This also shows their potential to act as antioxidant, anti-stress, anti-inflammatory, anti-bacterial, vaccine adjuvant, or immunity against diseases property