Add to ORKGAbstract: Based on the fact that a search for influenza antivirals among nucleoside analogues has drawn very little attention of chemists, the present study reports the synthesis of a series of 1,2,3-triazolyl nucleoside analogues in which a pyrimidine fragment is attached to the ribofuranosyl-1,2,3-triazol-4-yl moiety by a polymethylene linker of variable length. Target compounds were prepared by the Cu alkyne-azide cycloaddition (CuAAC) reaction. Derivatives of uracil, 6-methyluracil, 3,6-dimethyluracil, thymine and quinazolin-2,4-dione with ω-alkyne substituent at the N1 (or N5) atom and azido 2,3,5-tri-O-acetyl-D-β-ribofuranoside were used as components of the CuAAC reaction. All compounds synthesized were evaluated for antiviral activi...
A novel method for the synthesis of C(2) and C(6) modified purine nucleoside analogues has been deve...
A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via ...
Influenza viruses (Flu) are responsible for seasonal epidemics causing high rates of morbidity, whic...
A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragm...
Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2 /KI/K10) was used...
A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via ...
A new strategy for the synthesis of N(3) -benzoylated- and N(3) -benzylated N(1) -propargylquinazoli...
A new strategy for the synthesis of N(3) -benzoylated- and N(3) -benzylated N(1) -propargylquinazoli...
The synthesis and antiviral evaluation of a series of C5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)...
A novel series of ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonates was synthesized through...
A novel series of ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonates was synthesized through...
In the search for new anti-influenza virus (IV) compounds, we have identified the 1,2,4-triazolo[1,5...
In the search for new anti-influenza virus (IV) compounds, we have identified the 1,2,4-triazolo[1,5...
The copper catalyzed azide alkyne cycloaddition (CuAAC) reaction – the quintessential ‘click’ reacti...
A novel series of ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonates was synthesized through...
A novel method for the synthesis of C(2) and C(6) modified purine nucleoside analogues has been deve...
A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via ...
Influenza viruses (Flu) are responsible for seasonal epidemics causing high rates of morbidity, whic...
A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragm...
Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2 /KI/K10) was used...
A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via ...
A new strategy for the synthesis of N(3) -benzoylated- and N(3) -benzylated N(1) -propargylquinazoli...
A new strategy for the synthesis of N(3) -benzoylated- and N(3) -benzylated N(1) -propargylquinazoli...
The synthesis and antiviral evaluation of a series of C5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)...
A novel series of ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonates was synthesized through...
A novel series of ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonates was synthesized through...
In the search for new anti-influenza virus (IV) compounds, we have identified the 1,2,4-triazolo[1,5...
In the search for new anti-influenza virus (IV) compounds, we have identified the 1,2,4-triazolo[1,5...
The copper catalyzed azide alkyne cycloaddition (CuAAC) reaction – the quintessential ‘click’ reacti...
A novel series of ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonates was synthesized through...
A novel method for the synthesis of C(2) and C(6) modified purine nucleoside analogues has been deve...
A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via ...
Influenza viruses (Flu) are responsible for seasonal epidemics causing high rates of morbidity, whic...