Impact of COVID-19 and other viral infections of male fertility (Preliminary data)

Objective. To study the parameters of the hormonal status, hemostasis parameters, biochemical blood test and semen analysis in men of reproductive age who have undergone a new coronavirus infection (COVID-19). Material and methods. The study included 50 men who had a new coronavirus infection (COVID-19) and received treatment in hospital setting. The study was conducted 3 months later in the presence of positive IgG antibodies to COVID-19. All patients underwent a comprehensive examination, including the study of the hormonal profile, hemostasis parameters, biochemical blood test, identification of concomitant urological diseases, as well as semen analysis (concentration, mobility, morphology, MAR-test), according to WHO 2010 criteria. Results. The examination revealed a decrease in the level of total testosterone in 19 (38%) patients. The values ranged from 6.41 to 10 nmol/l (reference values 10.50—35.40 nmol/l). The biochemical blood analysis revealed the following changes: an increase in creatinine levels to 117—180 μM / L (reference values 80—115 μM/L) in 15 (30%) patients, total bilirubin (22—42.7 μM/L (refer-ence values 1.7—21.0 μMol/L) in 9 (18%) patients, alanine aminotransferase 43-109 U/L (reference values 0.0—41 U/L) in 19 (38%) patients, the level of aspartate aminotransferase was 45—82 U/L (with a norm of 0.0—40 U/L) in 10 (20%) patients Analysis of the hemo-stasis revealed hypercoagulation in 11 (22%) patients, and hypocoagulation in 6 (12%) patients. Abnormalities in the semen analysis were found in 10 (20%) patients with teratozoospermia in all the samples. In 8 (16%) patients, leukospermia was determined. There was a statistically significant decrease in the serum total testosterone level in 38% of patients (