This dissertation is based on my graduate research studying complex matter in multiple areas of biological physics. While the complex matter systems in each area differ vastly in scale and function, I use similar computational approaches on each to answer scientific queries about their structure and dynamics. In the first and second sections, I present how graph theory helps interpret actomyosin networks, which are complex biological active matter composed of filament, linker, and motor proteins. The results show how the network’s dynamics and structure are reshaped by motor and multivalent actin-binding proteins (“multilinkers”). The third section presents my collaborative work with James Liman and Carlos Bueno on the effect of the acti...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.Catalo...
Rich understanding of a complex system can often emerge from simple but carefully constructed models...
Self-assembling systems are prevalent across numerous scales of nature, lying at the heart of divers...
Actomyosin networks give cells the ability to move and divide. These networks contract and expand wh...
Cells employ networks of filamentous biopolymers to achieve shape changes and exert migratory forces...
Actin cytoskeleton arranges into distinct architectures to enable cell functions under different mec...
Actin, a highly conserved and abundant protein, constructs a fibrous matrix via actin binding protei...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.Includ...
Actomyosin contractility is a ubiquitous force-generating function of almost all eukaryotic organism...
Proteins are essential to supporting life in every living being. The three-dimensional shape of prot...
This dissertation sits at the intersection of mechanics and biology. Specifically, we devise mesosco...
The actin cytoskeleton is the scaffolding structure of eukaryotic cells, providing them with structu...
Actin, a major component of the cytoskeleton, is responsible for the shape and structural propertie...
In this dissertation, a new framework called bead-state model (BSM) for computer simulations of acti...
Motivation: Starting from linear chains of amino acids, the spontaneous folding of proteins into the...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.Catalo...
Rich understanding of a complex system can often emerge from simple but carefully constructed models...
Self-assembling systems are prevalent across numerous scales of nature, lying at the heart of divers...
Actomyosin networks give cells the ability to move and divide. These networks contract and expand wh...
Cells employ networks of filamentous biopolymers to achieve shape changes and exert migratory forces...
Actin cytoskeleton arranges into distinct architectures to enable cell functions under different mec...
Actin, a highly conserved and abundant protein, constructs a fibrous matrix via actin binding protei...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.Includ...
Actomyosin contractility is a ubiquitous force-generating function of almost all eukaryotic organism...
Proteins are essential to supporting life in every living being. The three-dimensional shape of prot...
This dissertation sits at the intersection of mechanics and biology. Specifically, we devise mesosco...
The actin cytoskeleton is the scaffolding structure of eukaryotic cells, providing them with structu...
Actin, a major component of the cytoskeleton, is responsible for the shape and structural propertie...
In this dissertation, a new framework called bead-state model (BSM) for computer simulations of acti...
Motivation: Starting from linear chains of amino acids, the spontaneous folding of proteins into the...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.Catalo...
Rich understanding of a complex system can often emerge from simple but carefully constructed models...
Self-assembling systems are prevalent across numerous scales of nature, lying at the heart of divers...