Role of TNF-alpha and Interleukin 6 Serum against Ovarian Reserve in Endometriosis Cysts: Peran TNF – a dan Interleukin 6 Serum terhadap Cadangan Ovarium pada Penderita Kista Endometriosis

Objective: To investigate the correlation between proinfl ammatory factors (TNF-alpha and IL-6) with ovarian reserve in patients with endometriosis cysts. Methods: This is a cross sectional study. The number of samples is 25 people. Sampling technique consecutive sampling. The study began in June 2019 until the number of samples was fulfi lled at the Obstetrics and Gynecology Polyclinic of the Dr. General Central Hospital M. Djamil Padang and at the Biomedical Laboratory of the Faculty of Medicine, Andalas University, Padang. To determine the correlation of TNF-alpha, IL-6, and AMH in patients with endometriosis cysts. Examination of TNF-alpha, IL-6, and AMH levels was carried out in a quantitative manner, using the ELISA method.Result: The mean AMH level was 2 ± 0.40 pmol / L andTNF-alpha level was 11.16 ± 4.79 pg / ml. Correlation of AMH level with TNF-alpha indicates the value of r = -0.049 which has weak strength and negative pattern means that the higher the TNF-alpha level, the lower the AMH level. The analysis showed that there was no correlation between TNF-alpha levels and AMH levels in patients with endometriosis cysts (p>0.05). Correlation of AMH levels with IL-6 shows the value of r = 0.35 which has moderate strength and positive pattern means that the higher the IL-6 level, the higher the AMH level. The analysis showed that there was no correlation between IL-6 levels and AMH levels in patients with endometriosis cysts (p> 0.05). Conclusions: There is a negative correlation of TNF-alpha levels with AMH levels in patients with endometriosis cysts, namely the higher TNF-alpha levels, the lower AMH levels and there is a positive correlation of IL-6 levels with AMH levels in patients with endometriosis cysts. Where the higher levels of IL-6, the higher levels of AMH. Keywords: AMH, endometriosis, TNF-alpha, IL-6