Cardio Protective Effect of Solanum nigrum Linn. in Isoproterenol Induced Myocardial Infarction in Rat

Myocardial infarction is one of the highest confronting metabolic syndromes which causemorbidity and mortality across the world. Recently, the renewed interests in medicinalplants have certain preventive action in treatment of cardiovascular disorder. The aim ofthe study was to investigate the cardio protective effects of Solanum nigrum Linn (hydroalcoholic extract) in isoproterenol induced myocardial infarction. The extracts wereinvestigated for in vivo cardio protective activity; the rats were pre treated with hydroalcoholic extract (75mg, 150mg and 300mg) for a period of 21 days. Standard drug(carvedilol - 2mg/kg) was used to compare the results with various parameters likebodyweight, ECG, heart weight, serum parameters and enzyme estimation. The rats fedwith extracts showed dose dependent cardio protective activity. Isoproterenol treatedanimals showed a marked increase in serum marker enzymes such as CK-MB, LDH,cholesterol, triglycerides, SGOT, SGPT. It was also observed that there was substantialincrease in heart and body weight along with endogenous enzyme levels of LPO. Therewas significant decrease in levels of SOD, CAT and GSH. Treatment group significantlyreduced the effects of isoproterenol induced myocardial infarction. Solanum nigrum hydroalcoholic extract treated groups possess cardio protective effect against isoproterenolinduced myocardial infarction