Estrogen Levels in the Three Trimesters of Pregnancy in Albino Rat.

An experimental investigation using DRG Estradiol ELISA Kit to determine the levels of estrogen in the serum of the first, second and third trimesters of pregnant and non-pregnant albino rats were undertaken.Twenty rats were divided into four groups of five rats each. Group one was the control group (non-pregnant rats); group two to four were pregnant rats in the first, second and third trimesters which were days 7, 14 and 21 respectively.Results from this study showed that the mean estrogen levels in albino rats were significantly increased (p<0.001) in first (14.681.36pg), second (16.26) and third (23.601.82pg) trimesters of pregnancy when compared to non pregnant control albino rats (9.740.50pg). This study confirmed that estrogen level increased in all stages of pregnancy with the highest level recorded in the third trimester.Analysis of variance indicated that there was significant difference (p<0.001) in estrogen levels across all the trimesters of pregnancy