Antipsychotic effect of aqueous stem bark extract of Amblygonocarpus andongensis in Wistar albino rats

The study of antipsychotic efect of the aqueous stem bark extract of Amblygonocarpus andongensis was carried out on amphetamine induced psychosis in 42 Wister albino rats weighingbetween 105 and 3052g using two indices feeding and locomotor activity. Twelve out of the 42 rats were divided into two groups; six per group. Group 1 and 2 received 15mg/kg body weight ooral amphetamine. Oral chlorpromazine (0.5mg/kg) was administered to group 2 rats in additon The remaining 30 rats were divided ino 5 groups: A, B, C, D and E, each group comprised 6 rats. All the groups received 15 mg/kg body weight of amphetamine but E received 05mg/kg oral chlorpromazine in addton. However, B, C and D received 450, 900 and 1350mg/kg bodyweght of Amblygonocarpus andongensis aqueous stem bark extract. Feeding and locomotor activities were measured in groups 1 and 2 and A, B, C, D and E rats respectively. The result showed that there were significant diferences in feeding and locomotor parameters between groups 1 and 2 and among groups A, B, C and E (