Levels Of Serum Intercellular And Vascular Adhesion Molecules In Insulin Dependent Diabetic Nephropathy Patients

The study evaluated the possible significant role of solubleintercellular and vascular adhesion molecule-1 (sICAM-1 andsVCAM-1), sE-selectin and interluekin-1β in developmentnephropathy in patients with insulin dependent diabetes mellitus(IDDM). This study included 60 patients with type 1 diabetes mellitus(IDDM), together with 20 healthy control subjects. Patients weredivided into 3 groups according to the onset of disease. All studiedgroups were subjected to clinical and laboratory evaluation of serumsoluble sICAM-1, sVCAM-1, sE-selectin, IL-1β in association withmicroalbumin, and CRP. A highly significant elevation of solubleadhesion molecules (sICAM-1, sVCAM-1 and sE-selectin) andmicroalbuminuria were observed in patients with IDDM, while therewas no significance difference in IL1-β in the same patients. Ourfindings may have clinical implications, since they may indicate that,these adhesion molecules are known as very strong marker for renalcomplications and the circulating forms of these adhesion moleculeshave been associated with clinical vascular events and all-causemortality in the renal population.Keywords: Adhesion molecules, IDDM, diabetic nephropath