The role of pyridoxal-5'-phosphate with simple sugars on caridovascular diseases prediction in rats

The objective of the present study is to assess the effect of different dietary simple sugars (sucrose, glucose and fructose) on the prediction of cardiovascular disease (CVD) risk factors, with regard to supplementation with high dose of vitamin B6 (500 mg/100 g diet) in the form of pyridoxal-5'-phosphate (PLP). It was concluded that, long term consumption of high carbohydrate diets increase the prediction of CVD by increasing plasma TG, total cholesterol and LDL-C levels. Dietary glucose was the best sugar used for substitution of starch, while fructose is considered as a risk factor for CVD. Plasma albumin showed little association with CVD. Pyridoxal-5'-phosphate and glucose in combination act in a synergistic manner through highly significant reduction in plasma LDL-C and significantly increase HDL-C levels throughout the first and second periods of the experiment. Supplementation with pyridoxal-5'-phosphate did not affect the plasma glucose levels on 21 days, but improves and normalizes the platelets count, and reduces the elevated TG levels via several mechanisms, and hence, reduces the risk factors leading to CVD. Keywords:Pyridoxal-5'-phosphate,Simple sugars, Cardiovascular disease Egyptian Journal of Biochemistry and Molecular Biology Vol. 24 (2) 2006: pp. 177-19