Deposition of Bechlomethasone Dipropionate and Salbutamol from a multidose dry powder inhaler device

The inhaler device is as important as the powder formulation for the successful development of dry powder inhalation products. As a result of current focus on tightening regulatory requirements, it is imperative that reproducibility of the metered dose of drug be ensured during the formulation, packaging and use. We developed a dry powder inhalation package in our laboratories consisting of drug formulation and a device (KCHALER, KCL Enterprises) for Phase 1 and Phase 2 Clinical studies. In this report, we present data on dose reproducibility obtained with the KCHALER device and the effect of type of mouthpiece attached to the KCHALER device on beclomethasone dipropionate (BMDP) and salbutamol (SALB) deposition in the Twin Impinger BP.Keywords: KCHALERTM device, dose reproducibility, mouthpiece, drug deposition, Twin Impinger B