Synthesis & anti-inflammatory activity of e-3-arylidene flavanones

Objective: To synthesize E-3-arylidene flavanones by one pot method and screen their anti-inflammatory activity. Method: A set of four E-3 arylidene flavanones were synthesized by simple base catalysed condensation of appropriate aryl aldehydes and p-methoxy acetophenone. Screening the anti-inflammatory activity by carageenan induced paw edema method. Results: A set of four E-3 arylidene flavanones were synthesized. All four were found to exhibit anti-inflammatory action. Conclusion: Due to the structural similarity with those of natural flavanones, all the synthesized compounds were expected to exhibit anti-inflammatory activity and all were found to exhibit anti-inflammatory action. Keywords: E-3 Arylidene flavanone, p-methoxy acetophenone, One- pot method, anti-inflammatory activity, natural flavanone.Highland Medical Research Journal Vol. 5 (1) 2007 pp. 20-2