Evaluation Of Selenium Supplementation Alone, A Combination Of Selenium And Vitamin E And Combination Of Selenium And Low Dose Diminazine Aceturate In Trypanosoma brucei Infected Rats

The effect of selenium supplementation alone and a combination of selenium and Vitamin E or low dose diminazene aceturate (berenil) was investigated in Trypanosoma brucei brucei infected rats. The effect of the selenium supplementation and its combinations were assessed using the parasitaemia, changes in body weight, temperature, packed cell volume (PCV), red blood cell (RBC) count, total leucocyte count and differential leucocyte count. Selenium alone and its combination with Vitamin E could not clear the infection and when it was combined with low dose berenil, it could not prolong the relapse interval. Selenium supplementation could not improve PCV and RBC values significantly (P>0.05). Combination of selenium and vitamin E and combination berenil and selenium improved the WBC counts significantly (