Knowledge, Attitude and Willingness to Screen Younger Infants for Sickle Cell Disease among Mothers attending Immunization Clinic in an Urban Community in Lagos, Nigeria

Background: Over 300,000 babies are born worldwide with sickle cell disease, mostly in low- and middle-income countries with the majority of these births in Africa. Nigeria has the largest population of people with sickle cell disease with about 150,000 children born with the disease every year. This study assessed the knowledge, attitude and willingness to screen younger infants for sickle cell disease among mothers attending immunization clinic in an urban community in Lagos, Nigeria.Methods: A cross-sectional descriptive study was carried out at primary health care centres in Somolu Local Government Area in Lagos, Nigeria. Two hundred and ninety-one mother-infant pairs were consecutively recruited from August 2019 to January 2020. Data were collected with a pre-tested, interviewer-administered questionnaire. The analysis was done using SPSS version 22 software. Univariate and bivariate analysis were conducted with the level of significance set at p<0.05.Results: The mean age of respondents was 29.9 ± 5.4 years. Most 212 (72.9%) were aware of sickle cell disease. One hundred and fifty-one (71.2%) of those who were aware of sickle cell disease had good knowledge while 148 (69.8%) had a positive attitude towards SCD prevention. Majority of the respondents 180 (84.9%) were willing to screen their infants for sickle cell disease. A statistically significant association was found between good knowledge and positive attitude towards SCD (p<0.001).Conclusion: There is the need for increased education of mothers of younger infants attending routine immunization clinic about SCD for better knowledge, attitude and willingness for early infants screening of SCD