Physicochemical and powder properties of alpha- and microcrystalline-cellulose derived from maize cobs

Cob alpha-celluloses (CAC) was extracted from maize cobs by defibering, delignification and bleaching; then subjected to acid hydrolysis to obtain Cob- microcrystalline-cellulose (CMCC). Their physicochemical properties were evaluated and compared with those of Avicel®, a commercial variety of microcrystalline cellulose. Identification tests, and tests for possible contaminants were performed on them. Their powder properties were determined to ascertain their suitability and usefulness in tabletting. The results showed that the extraction process was adequate, as pure alpha cellulose was obtained. Also, the CMCC extracted was found to have comparable powder properties with Avicel®; and one can say that it can be used for similar function as Avicel® in pharmaceutical processes. Key Words: Cob alpha-cellulose (CAC); Cob microcrystalline-cellulose (CMCC);Avicel®; Physicochemical powder properties. Journal of Pharmacy and Bioresources Vol.1(1) 2004: 41-4