Synergistic antiosteoporotic effect of Lepidium Sativum and alendronate in glucocorticoid-induced osteoporosis in wistar rats

  • Elshal, MF
  • Almalki, AL
  • Hussein, HK
  • Khan, JA
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Publication date
August 2013
Publisher
African Journals Online (AJOL)
Language
English

Abstract

Alendronate belongs to a class of drugs called bisphosphonates. Bisphosphonates (BP) therapy is a vital option to reduce the risk of bone fracture in people who suffer from osteoporosis. Yet, bisphosphonate have displayed several side effects. Lepidium sativum (LS) seeds have been used in traditional folk medicine to heal fractured bones. However, there is a dearth of information on the impact of LS on bone metabolism especially in cases of glucocorticoids induced osteoporosis. Therefore, the aim of the study was to compare the biochemical bone markers and histological responses of LS alone (6 g of LS seeds in diet daily, n=8), ALD (alendronate, 70 mg/kg s.c.; n=8) alone, or LS and ALD combined in a rat model of glucocorticoid-induced osteo...

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