Acute Toxicity Determination Of Two New Benzothiazino Phenoxazine Dyestuffs In Mice

Two new heterocyclic benzothiazinophenoxazine dyestuffs have been subjected to acute toxicity test using mice as the test animal. For each dyestuff, a total of thirty albino mice with average weight range of 14 - 25g were used. The first dyestuff-dibenzo[a,j][1,4]benzothiazino[3,2-c]phenoxazine had LD50 value of 291.7mg/kg while the second dyestuff-8,-chloro-11-oxa-10-thia,9,18-triazadibenzo[a,r]pentaphene had LD50 value of 363.07mg/kg. These values are within the limits of acceptable values for dyestuffs. KEY WORDS: Toxicity, LD50, Mice, Benzothiazino Phenoxazine. J.Expt. & Clin. Anat. 2(2) 2003: 20-2