Histopathologic effect of potassium bromate on the kidney of adult wistar rats.

Objective: We aimed to demonstrate the histopathologic effects of potassium bromate (KBrO ) on the kidney tissues of rats following 3short-term and long-term exposures.Method: Twenty young wistar rats of weights 180-250g were divided into three groups. The control group A was sub-divided into two groups of three rats each and orally administered with 1ml of distilled water daily for 7 days and 21 days respectively; the experimental groups B and C were administered with 75 mg/kg body weight/day dosage of KBrO orally for 1 week and 3 weeks 3 respectively.Results: Histopathological examination of the experimental groups showed haemorrhagic, necrotic and degenerative changes in the kidney tissues compared with the control group, which maintained normal kidney tissues. These histological changes were marked in group C animals exposed to KBrO for 3 weeks compared to those exposed for 1 week. 3 Conclusion: The present study indicated that both short-term and long-term exposures to sub-lethal dose of KBrO caused alterations 3in the histology of the kidney of wistar rats. These alterations may account for the various nephrotoxic effects associated with exposure to KBrO In addition, some of the histopathologic effects were marked in long-term compared to short-term exposure to 3. KBrO , thus indicating duration-dependent effect of KBrO consumption.Key Words: Potassium bromate, Wistar rats, Histopathology, Kidneys, Nephrotoxi