Silica-supported Preyssler Nanoparticles as New Catalysts in the Synthesis of 4(3H)-Quinazolinones

A new and efficient method for the preparation of 4(3H)-quinazolinones from the condensation of anthranilic acid, orthoester and substituted anilines, in the presence of catalytic amounts of silica-supported Preyssler nanoparticles is reported. The catalyst performs very well in comparison with other catalysts reported before. An important advantage of this catalyst is the ease of separating it from the reaction mixture, as well as the fact that it could be recycled a number of times.Keywords: 4(3H)-Quinazolinones, recyclable catalyst, silica-supported Preyssler nanoparticles, heteropolyacid