Effect of Ethanol Leaf Extract of Newboulda Laevis on Blood Glucose Levels of Diabetic Rats

Purpose: To investigate anti-diabetic effect of the ethanol leaf extract of Newbouldia laevis (P. Beauv) in alloxan-induced diabetic rats.Methods: Alloxan (150 mg/kg) was administered to wistar albino rats via the intraperitoneal route. The diabetic rats were then placed in 5 groups, following stabilization of hyperglycemia. The first group was untreated, the next three groups received, each day, 100, 200 and 400 mg/kg body weight of the ethanol extract Newbouldia laevis and the fifth group received a reference standard, glibenclamide (5 mg/kg). Treatment was via the oral route for 14 days and fasting blood sugar level was monitored over this period. Acute toxicity (oral and intraperitoneal) studies on the extract was carried out, as well as phytochemical screening of the extract.Results: All doses of the extract (100, 200, and 400 mg/kg) significantly (p < 0.05, p < 0.0001,