Anti-inflammatory and analgesic effects of Careya arborea stem bark in experimental animal models

The present study was carried out to evaluate the anti-inflammatory and analgesic activities of methanol extract of Careya arborea (MECA). The effects of MECA on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw oedema and cotton pellet induced granuloma respectively. Analgesic effect of MECA was evaluated in acetic acid induced writhing and hotplate tests. The anti-oedema effect of MECA was compared with indomethacin 10 mg/kg orally. In acute phase of inflammation a maximum inhibition of 50.56, 48.86, 47.12 and 48.23% (