Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy
- Nyangulu, Wongani J.S.
- Mwinjiwa, Edson
- Divala, Titus H.
- Mungwira, Randy G.
- Nyirenda, Osward
- Kanjala, Maxwell
- Mbambo, Gillian
- Mallewa, Jane
- Taylor, Terrie E.
- Laurens, Matthew B.
- Laufer, Miriam K.
- van Oosterhout, Joep J.
Publication date
May 2017
DOI Publisher
African Journals Online (AJOL) Language
EnglishAbstract
We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether–lumefantrine may have played a causative role in the recurrent malaria our patients experienced
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