Screening and Prophylactic Mastectomy Recommendations by Genomic Biomarker for Breast Cancer Risk in Unaffected Women

A major cause of cancer related mortality in the United States is breast cancer. A significant portion of breast cancer cases are inherited and more is learned about the genetics of hereditary breast cancer risk each year. Screening and risk-reducing surgery recommendations can improve outcomes through early detection and disease prevention. As genetic markers for breast cancer risk are identified, it is important to update recommendations for screening and risk reducing surgery. This article aims to summarize and discuss current recommendations for non-BRCA, moderate to high risk genomic biomarkers for unaffected women