We consider a stochastically continuous, affine Markov process in the sense of Duffie, Filipovic and Schachermayer, with cadlag paths, on a general state space D, i.e. an arbitrary Borel subset of Rd. We show that such a process is always regular, meaning that its Fourier-Laplace transform is differentiable in time, with derivatives that are continuous in the transform variable. As a consequence, we show that generalized Riccati equations and Levy-Khintchine parameters for the process can be derived, as in the case of D=Rm+×Rn studied in Duffie, Filipovic and Schachermayer (2003). Moreover, we show that when the killing rate is zero, the affine process is a semi -martingale with absolutely continuous characteristics up to its time of explos...