Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain states. Restoring proper synaptic inhibition is a well-established rational therapeutic approach explored by several pharmaceutical companies. A particular challenge arises from the need for site-specific intervention to avoid deleterious side effects such as sedation, addiction, or impaired motor control, which would arise from wide-range facilitation of inhibition. Specific targeting of glycinergic inhibition, which dominates in the spinal cord and parts of the hindbrain, may help reduce these side effects. Selective targeting of the α3 subtype of glycine receptors (GlyRs), which is highly enriched in the superficial layers of the spinal dorsa...
Glycine receptors (GlyRs) play an important role in inhibiting neurone activity in the spinal cord. ...
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal co...
Strychnine−sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brain...
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain sta...
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain sta...
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain sta...
Glycinergic neurotransmission has long been known for its role in spinal motor control. During the l...
Glycinergic neurotransmission has long been known for its role in spinal motor control. During the l...
Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the s...
Although glycine receptor Cl- channels (GlyRs) have long been known to mediate inhibitory neurotrans...
Among the myriad of cellular and molecular processes identified as contributing to pathological pain...
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal co...
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal co...
Abstract Background Glycine receptors (GlyRs) are involved in the development of spinal pain sensiti...
Alterations in synaptic transmission within the spinal cord dorsal horn play a key role in the devel...
Glycine receptors (GlyRs) play an important role in inhibiting neurone activity in the spinal cord. ...
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal co...
Strychnine−sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brain...
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain sta...
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain sta...
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain sta...
Glycinergic neurotransmission has long been known for its role in spinal motor control. During the l...
Glycinergic neurotransmission has long been known for its role in spinal motor control. During the l...
Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the s...
Although glycine receptor Cl- channels (GlyRs) have long been known to mediate inhibitory neurotrans...
Among the myriad of cellular and molecular processes identified as contributing to pathological pain...
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal co...
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal co...
Abstract Background Glycine receptors (GlyRs) are involved in the development of spinal pain sensiti...
Alterations in synaptic transmission within the spinal cord dorsal horn play a key role in the devel...
Glycine receptors (GlyRs) play an important role in inhibiting neurone activity in the spinal cord. ...
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal co...
Strychnine−sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brain...