Graviola fruit extraction by ionic liquid microwave-assisted extraction (IL-MAE)

This chapter discusses the extraction method of Graviola fruit using ionic liquid microwave-assisted extraction (IL-MAE). Three parameters—irradiation power, solid/liquid (s/l) ratio, and extraction time—were investigated to obtain optimum extraction process resulting in a high yield and a low IC50 value for the anti-proliferation assay. The results showed that the extraction time of 1.74 min, the irradiation power of 300Wand the s/l ratio of 1:25 gave the highest extraction yield of 67.6%. Whereas the extraction time of 3 min instead of 2.98 min, the irradiation power of 700Winstead of 690W, and the s/l ratio of 1:39 produced an average IC50 of 4.75 ± 0.36 μg/mL for MCF7 and 10.56 ± 2.04 μg/mL for HT29. The IL-MAE technique was found to be effective in the extraction of plant fruit as described in the case study