Obesity and long-term outcomes after incident stroke: a prospective population-based cohort study

Akyea, Ralph K.
Doehner, Wolfram
Iyen, Barbara
Weng, Stephen F.
Qureshi, Nadeem
Ntaios, George

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Publication date

December 2021

DOI

10.1002/jcsm.12818

Publisher

Wiley

Abstract

Background: The association between obesity, major adverse cardiovascular events (MACE), and mortality in patients with incident stroke is not well established. We assessed the relationship between body mass index (BMI) and MACE in patients with incident stroke. Methods: The population-based cohort study identified 30702 individuals from the Clinical Practice Research Datalink (CPRD GOLD) and Hospital Episode Statistics (HES) databases from the United Kingdom. Individuals were aged ≥18years with incident stroke between 1-1-1998 and 31-12-2017, a BMI recorded within 24months before incident stroke, and no prior history of MACE. BMI was categorized as underweight (<18.5kg/m2), normal (18.5–24.9kg/m2), overweight (25.0–29.9kg/m2), obesity clas...