Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development
The reversible phosphorylation of proteins regulates almost all aspects of cell life, while abnormal...
International audienceProtein kinases and phosphatases play crucial roles in all the major cellular ...
Mitogen-activated protein kinase (MAPK) pathways are evolutionarily conserved in all eukaryotes and ...
Proteins are the work horses of the cell. As regulators of protein function, protein kinases are inv...
Protein phosphorylation regulates most aspects of cell life, whereas abnormal phosphorylation is a c...
The protein kinase superfamily is one of the most important families of enzymes in molecular biology...
Protein kinases, a diverse group of cellular enzymes, play fundamental roles in maintaining normal c...
The protein kinase superfamily is one of the most important families of enzymes in molecular biology...
International audienceBiological matter is organized in functional networks of different natures amo...
Deregulation of a broad range of protein kinases has been linked to the development and growth of ca...
Abstract Protein phosphorylation is an important post‐transcriptional modification involving an extr...
The reversible phosphorylation of proteins regulates almost all aspects of cell life, while abnormal...
International audienceProtein kinases and phosphatases play crucial roles in all the major cellular ...
Mitogen-activated protein kinase (MAPK) pathways are evolutionarily conserved in all eukaryotes and ...
Proteins are the work horses of the cell. As regulators of protein function, protein kinases are inv...
Protein phosphorylation regulates most aspects of cell life, whereas abnormal phosphorylation is a c...
The protein kinase superfamily is one of the most important families of enzymes in molecular biology...
Protein kinases, a diverse group of cellular enzymes, play fundamental roles in maintaining normal c...
The protein kinase superfamily is one of the most important families of enzymes in molecular biology...
International audienceBiological matter is organized in functional networks of different natures amo...
Deregulation of a broad range of protein kinases has been linked to the development and growth of ca...
Abstract Protein phosphorylation is an important post‐transcriptional modification involving an extr...
The reversible phosphorylation of proteins regulates almost all aspects of cell life, while abnormal...
International audienceProtein kinases and phosphatases play crucial roles in all the major cellular ...
Mitogen-activated protein kinase (MAPK) pathways are evolutionarily conserved in all eukaryotes and ...