Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most individuals with features of non-syndromic inherited RCC do not harbor variants in the most commonly tested renal cancer predisposition genes (CPGs). We investigated whether undiagnosed cases might harbor mutations in CPGs that are not routinely tested for by testing 118 individuals with features suggestive of inherited RCC (family history of RCC, two or more primary RCC aged <60 years, or early onset RCC ≤46 years) for the presence of pathogenic variants in a large panel of CPGs. All individuals had been prescreened for pathogenic variants in the major RCC genes. We detected pathogenic or likely pathogenic (P/LP) variants of potential clinic...
According to the latest knowledge, hereditary kidney cancers may account for 5–8% of all kidney canc...
BackgroundEvery year more than 800 patients in Denmark are diagnosed with renal cell carcinoma (RCC)...
The genetic cause of some familial nonsyndromic renal cell carcinomas (RCC) defined by at least two ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes, but the genetic ar...
BACKGROUND: Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes but the...
Background Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes but the...
BACKGROUND: Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes but the...
Renal Cell Carcinomas (RCC) are a diverse group of histologically and genetically distinct renal neo...
© 2020, The Author(s). Pathogenic variants (PVs) in multiple genes are known to increase the risk of...
PURPOSE: Genetic factors have been implicated in the pathogenesis of renal cell carcinoma (RCC), wit...
According to the latest knowledge, hereditary kidney cancers may account for 5–8% of all kidney canc...
BackgroundEvery year more than 800 patients in Denmark are diagnosed with renal cell carcinoma (RCC)...
The genetic cause of some familial nonsyndromic renal cell carcinomas (RCC) defined by at least two ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most ...
Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes, but the genetic ar...
BACKGROUND: Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes but the...
Background Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes but the...
BACKGROUND: Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes but the...
Renal Cell Carcinomas (RCC) are a diverse group of histologically and genetically distinct renal neo...
© 2020, The Author(s). Pathogenic variants (PVs) in multiple genes are known to increase the risk of...
PURPOSE: Genetic factors have been implicated in the pathogenesis of renal cell carcinoma (RCC), wit...
According to the latest knowledge, hereditary kidney cancers may account for 5–8% of all kidney canc...
BackgroundEvery year more than 800 patients in Denmark are diagnosed with renal cell carcinoma (RCC)...
The genetic cause of some familial nonsyndromic renal cell carcinomas (RCC) defined by at least two ...