An Epidemiological Study on Selected Blood Parameters among COVID-19 Infected patient in a Tertiary Care Centre of India

Background:Patients with COVID-19 present with multiple hematological abnormalities.Objectives: This study investigated the impact of selected blood markers in COVID-19 positive patients and to determine any correlation with disease severity.Methods: This cross-sectional study was conducted in a tertiary care dedicated COVID hospital . Study period was March 2021 to April 2021 All moderate and severe category COVID 19 positive patients those were admitted in study period , were included as study participants by complete enumeration method. Blood samples were collected during admission at emergency and Blood parameters like total leukocyte count(TLC), C-reactive Protein(CRP), Neutrophil to Lymphocytes ratio(NLR), Albumin, Globulin, Alanine aminotransferase(ALT), Aspartate Aminotransferase(AST), alkaline phosphatase (ALP), sodium, potassium, urea, creatinine were assessed.Results: Mean of CRP was 33.91 mg/L. Mean of NLR and TLC were 5.8 and 11644.9/cc respectively . Lymphopenia was seen with lowest value was 4% and mean 20.16. Hyponatremia and hypokalaemia were seen 45.9% and 17.3% patients respectively. Blood urea and creatinine were raised almost 44.9 % and 28.6% patients respectively. Only 12.2 % patients had hypoalbuminemia. Positive correlation with statistical significant association was found with NLR with CRP(R=0.225, p=0.026)and NLR with TLC (R=0.625, p=0.000). Negative correlation was found with CRP and albumin though no statistical significant was seen (R= -.024, p=0.813).Conclusion: With this findings it can be concluded that routine blood parameters like CRP, TLC, NLR, albumin, urea ,creatinine, sodium and potassium should be advised all patients irrespective of disease category as a screening tool for disease progression