Optimizing the performance of general finite single-server acyclic queueing networks is a challenging problem and has been the subject of many studies. The version of the optimization problem treated here considers the minimization of the buffer areas and the service rates simultaneously with the maximization of the throughput. These are conflicting objectives, and the most appropriate methodology appears to be a multi-objective methodology. In fact, algorithms have previously been proposed, and the aim here is to show that the use of a mixed methodology can occasionally improve solutions without a significant increase in the computational costs. This paper shows that improvements in throughput can be achieved through a solution of...