Production of chiral alcohols from racemic mixtures by integrated heterogeneous chemoenzymatic catalysis in fixed bed continuous operation

[EN] Valuable chiral alcs. have been obtained from racemic mixts. with an integrated heterogeneous chemoenzymic catalyst in a two consecutive fixed catalytic bed continuous reactor system. In the first bed the racemic mixt. of alcs. is oxidized to the prochiral ketone with a Zr-Beta zeolite and using acetone as the hydrogen acceptor. In the second catalytic bed the prochiral ketone is stereoselectively reduced with an alc. dehydrogenase (ADH) immobilized on a two dimensional (2D) zeolite. In this process, the alc. (isopropanol) formed by the redn. of acetone in the first step reduces the cofactor in the second step, and the full reaction cycle is in this way internally closed with 100% atom economy. A conversion of about 95% with ~100% selectivity to either the (R) or the (S) alc. has been obtained for a variety of racemic mixts. of alcsThe research leading to these results has received funding from the Spanish Ministry of Science, Innovation and Universities through "Severo Ochoa" Excellence Programme (SEV-2016-0683) and the PGC2018-097277-B-100(MCIU/AEI/FEDER, UE) project. J. M. C. thanks to Universitat Politecnica de Valencia for a predoctoral fellowship.Carceller-Carceller, JM.; Mifsud, M.; Climent Olmedo, MJ.; Iborra Chornet, S.; Corma Canós, A. (2020). Production of chiral alcohols from racemic mixtures by integrated heterogeneous chemoenzymatic catalysis in fixed bed continuous operation. Green Chemistry. 22(9):2767-2777. https://doi.org/10.1039/c9gc04127c27672777229R. A. Sheldon , Chirotechnology: Industrial synthesis of optically active compounds , Marcel Dekker, Inc. , New York , 1993Okamoto, Y., & Ikai, T. (2008). Chiral HPLC for efficient resolution of enantiomers. 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