Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-κB signaling. Insights into the sources of IKKα(p45) activation and its downstream substrates in the nucleus remain to be defined. Here, we discover that IKKα(p45) is rapidly activated by DNA damage independent of ATM-ATR, but dependent on BRAF-TAK1-p38-MAPK, and is required for robust ATM activation and efficient DNA repair. Abolishing BRAF or IKKα activity attenuates ATM, Chk1, MDC1, Kap1, and 53BP1 phosphorylation, compromises 53BP1 and RIF1 co-recruitment to sites of DNA lesions, and inhibits 53BP1-dependent fusion of dysfunctional telomeres. Furthermore, IKKα or BRAF...
IKKβ (IκB kinase β) is a core component of signalling pathways that control the activation of NF-κB ...
Chemotherapy agents have been shown to induce the transcription factor NF-κB and subsequent chemores...
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a kinase principally known as a po...
Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that is induced by the MAP kina...
Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by the ...
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and m...
KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorect...
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked...
Activation of the IKK-NFκB pathway increases the resistance of cancer cells to ionizing radiation (I...
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked...
Cancer therapy has improved considerably in the last years; however, therapeutic resistance is still...
SummaryNuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been...
Cancer is the second leading cause of death in the USA and it is expected to surpass heart diseases ...
In response to genotoxic stress induced by DNA double-stranded breaks (DSBs), the inhibitor of &kapp...
proteins can assemble into a variety of homo- and heterodimers that bind to κB sites on DNA and indu...
IKKβ (IκB kinase β) is a core component of signalling pathways that control the activation of NF-κB ...
Chemotherapy agents have been shown to induce the transcription factor NF-κB and subsequent chemores...
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a kinase principally known as a po...
Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that is induced by the MAP kina...
Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by the ...
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and m...
KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorect...
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked...
Activation of the IKK-NFκB pathway increases the resistance of cancer cells to ionizing radiation (I...
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked...
Cancer therapy has improved considerably in the last years; however, therapeutic resistance is still...
SummaryNuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been...
Cancer is the second leading cause of death in the USA and it is expected to surpass heart diseases ...
In response to genotoxic stress induced by DNA double-stranded breaks (DSBs), the inhibitor of &kapp...
proteins can assemble into a variety of homo- and heterodimers that bind to κB sites on DNA and indu...
IKKβ (IκB kinase β) is a core component of signalling pathways that control the activation of NF-κB ...
Chemotherapy agents have been shown to induce the transcription factor NF-κB and subsequent chemores...
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a kinase principally known as a po...