Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study
- Tura, A.
- Grespan, E.
- Göbl, C. S.
- Koivula, R. W.
- Franks, P. W.
- Pearson, E. R.
- Walker, M.
- Forgie, I. M.
- Giordano, G. N.
- Pavo, I.
- Ruetten, H.
- Dermitzakis, E. T.
- McCarthy, M. I.
- Pedersen, O.
- Schwenk, J. M.
- Adamski, J.
- De Masi, F.
- Tsirigos, K. D.
- Brunak, S.
- Viñuela, A.
- Mahajan, A.
- McDonald, T. J.
- Kokkola, T.
- Vangipurapu, J.
- Cederberg, H.
- Laakso, M.
- Rutters, F.
- Elders, P. J. M.
- Koopman, A. D. M.
- Beulens, J. W.
- Ridderstråle, M.
- Hansen, T. H.
- Allin, K. H.
- Hansen, T.
- Vestergaard, H.
- Mari, A.
DOIAbstract
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose, IFG; impaired glucose tolerance, IGT; HbA1c-prediabetes, IA1c), two defects (IFG+IGT, IFG+IA1c, IGT+IA1c), or all defects (IFG+IGT+IA1c). Beta-cell function (BCF) and insulin sensitivity (IS) were assessed from OGTT. At baseline, when pooling participants with isolated defects, they showed impairment in both BCF and IS compared to healthy controls. Pooled groups with two or three defects showed progressive further deterio...
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