AbstractUSP7 is a nuclear deubiquitylase (DUB) with multiple cancer-associated substrates for which selective inhibitors are available, yet it remains unclear how the pleiotropic effects of USP7 are regulated. We report that S18-phosphorylation does not influence USP7 catalytic activity but instead confers selectivity for protein interactions. In particular, non-S18-phosphorylatable USP7 preferentially interacts with USP11 and TRIM27, together with TCEAL1 and TCEAL4 whose functions are unknown. Intriguingly, USP7 can interact with two cellular forms of TCEAL4, but USP11 only interacts with a lower abundance K142 mono-ubiquitylated form (TCEAL4-Ub), which can scaffold a complex containing both DUBs. Whilst USP11 and TCEAL4 are both USP7 subs...
Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiqui...
12 p.Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis...
Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents ba...
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags...
The ubiquitin-specific protease 7 (USP7) is a deubiquitylating enzyme that regulates many important ...
The ubiquitin-specific protease USP7/HAUSP regulates p53 and MDM2 levels, and cellular localization ...
The major part of this thesis describes studies of human ubiquitin-specific protease 7 (USP7), a deu...
Ubiquitin specific proteases (USPs) are a class of enzymes involved in myriad cellular processes. On...
Ubiquitylation is a well-defined regulator of the cell cycle, as temporal degradation of cell cycle ...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
SummaryThe human USP7 deubiquitinating enzyme was shown to regulate many proteins involved in the ce...
© 2018 Ward et al. Ubiquitin-specific protease 15 (USP15) regulates important cellular processes, in...
Eukaryotic cells perform a range of complex processes, some essential for life, others specific to c...
USP7 is a highly abundant deubiquitinating enzyme (DUB), involved in cellular processes including DN...
Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiqui...
12 p.Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis...
Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents ba...
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags...
The ubiquitin-specific protease 7 (USP7) is a deubiquitylating enzyme that regulates many important ...
The ubiquitin-specific protease USP7/HAUSP regulates p53 and MDM2 levels, and cellular localization ...
The major part of this thesis describes studies of human ubiquitin-specific protease 7 (USP7), a deu...
Ubiquitin specific proteases (USPs) are a class of enzymes involved in myriad cellular processes. On...
Ubiquitylation is a well-defined regulator of the cell cycle, as temporal degradation of cell cycle ...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to...
SummaryThe human USP7 deubiquitinating enzyme was shown to regulate many proteins involved in the ce...
© 2018 Ward et al. Ubiquitin-specific protease 15 (USP15) regulates important cellular processes, in...
Eukaryotic cells perform a range of complex processes, some essential for life, others specific to c...
USP7 is a highly abundant deubiquitinating enzyme (DUB), involved in cellular processes including DN...
Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiqui...
12 p.Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis...
Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents ba...