Objectives: An orally administered anticancer drug has been poor drug absorption; drug resistance and metabolism, which alters the bioavailability of drugs. An in situ intestine perfusion technique is developing under the different perfusion rates in the presence of drug inducers and inhibitors of cytochrome isoenzyme-P (CYP)-3A4 and P-glycoprotein (P-gp) for drug concentrations. Materials and Methods: The modified in situ intestinal perfusion technique was developed and followed to obtain the portal and hepatic venous blood samples paralleled at different perfusion time and flow rates of 0.05, 0.1, 0.5, and 1.0 mL/min using the imatinib (1 mg/mL) drug alone and in the presence of drug inducer and drug inhibitor for the period of 3 h. The i...
PURPOSE: The aims of the study are to develop and evaluate an in vitro rat intestine segmental perfu...
PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotec...
The intestine plays an important role in uptake and metabolism of physiological, but also xenobiotic...
The present study explored the feasibility of a differential setup for the in situ perfusion techniq...
Dissertation (Ph.D.)--University of Kansas, Pharmaceutical Chemistry, 2007.Preclinical drug developm...
PhD ThesisA reduction in oral bioavailability of a wide range of drug compounds may occur following ...
P-glycoprotein (P-gp) and cytochrome P450 3A (CYP3A) are differentially expressed along the intestin...
Drug efflux by intestinal P-glycoprotein (P-gp) is known to decrease the oral bioavailability of man...
Purpose: The aims of the study are to develop and evaluate an in vitro rat intestine segmental perfu...
First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was deve...
AbstractOral administration is the most commonly used route for drug treatment. Intestinal cytochrom...
Objective: The present research work aims to study the intestinal transport of Paclitaxel and to pre...
Background/PurposeFirst-pass effect has been an important concern for oral pharmaceuticals. An in vi...
Overexpression of P-glycoprotein (Pgp) increases multidrug resistance (MDR) in cancer, which greatly...
Contains fulltext : 80456.pdf (publisher's version ) (Closed access)Cytochrome P45...
PURPOSE: The aims of the study are to develop and evaluate an in vitro rat intestine segmental perfu...
PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotec...
The intestine plays an important role in uptake and metabolism of physiological, but also xenobiotic...
The present study explored the feasibility of a differential setup for the in situ perfusion techniq...
Dissertation (Ph.D.)--University of Kansas, Pharmaceutical Chemistry, 2007.Preclinical drug developm...
PhD ThesisA reduction in oral bioavailability of a wide range of drug compounds may occur following ...
P-glycoprotein (P-gp) and cytochrome P450 3A (CYP3A) are differentially expressed along the intestin...
Drug efflux by intestinal P-glycoprotein (P-gp) is known to decrease the oral bioavailability of man...
Purpose: The aims of the study are to develop and evaluate an in vitro rat intestine segmental perfu...
First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was deve...
AbstractOral administration is the most commonly used route for drug treatment. Intestinal cytochrom...
Objective: The present research work aims to study the intestinal transport of Paclitaxel and to pre...
Background/PurposeFirst-pass effect has been an important concern for oral pharmaceuticals. An in vi...
Overexpression of P-glycoprotein (Pgp) increases multidrug resistance (MDR) in cancer, which greatly...
Contains fulltext : 80456.pdf (publisher's version ) (Closed access)Cytochrome P45...
PURPOSE: The aims of the study are to develop and evaluate an in vitro rat intestine segmental perfu...
PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotec...
The intestine plays an important role in uptake and metabolism of physiological, but also xenobiotic...