THE EFFECT OF HYDROLYZED VIRGIN COCONUT OIL ON LIPID PROFILE AND LIVER ENZYMES IN DYSLIPIDEMIC RATS

Objective: The objective of this study was to investigate the effect of virgin coconut oil (VCO) and hydrolyzed VCO (HVCO) on lipid profile and liver enzymes in dyslipidemic rats.Methods: VCO was hydrolyzed using lipase from Rhizomucor miehei (active on sn-1,3 position). Thirty male rats (150–200 g) were induced with 2 ml/kg body weight (BW) egg yolk and lard oil twice a day for 30 days. Rats were divided into six groups which were given with sodium carboxymethylcellulose 0.5%, atorvastatin, VCO (4 and 6 ml/kg BW), and HVCO (4 and 6 ml/kg BW). Lipid profile including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), and liver enzymes including serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were measured after 14 days of treatment.Results: The results of this study show that VCO and HVCO improve lipid profile (decrease in TC, TG, LDL-C, and VLDL-C, but increase in HDL-C). VCO and HVCO also lower atherogenic index, TC/HDL-C ratio, LDL-C/HDL-C ratio, SGOT, and SGPT. Result shows that HVCO improves lipid profile and liver enzymes better than VCO does.Conclusion: VCO and HVCO improve lipid profile in dyslipidemic rats, not atherogenic, and not toxic to the liver. HVCO causes better lipid profile improvement, especially with 6 ml/kg BW dosage