RELATIONSHIP BETWEEN SOME IMMUNOLOGICAL FACTORS AND TYPE 2 DIABETES MELLITUS IN IRAQI PATIENTS

Objective: To determine whether elevated levels of the inflammatory markers interleukin 6 (IL-6), interleukin 8 (IL-8) and insulin – like growth factor-1 are associated with development of type 2 DM in Iraqi sample.Methods: A total number of 150 samples in this study, including 75 diabetes mellitus patients and 75 healthy people (control) This study was conducted from August 2016 to February 2017. All samples were collected from Anbar city, Iraq. Serum concentrations of IL-6, IL-8 and IGF. were determined using a commercially available enzyme-linked immune sorbent assay (ELISA).Results: The results of the present study showed that there was a difference in the mean values of IL-6, IL-8 and IFG between the group of patients with type 2 diabetes and the control group The results showed a negative correlation between IL-6 and IL-8, while the correlation between IL-6 and IGF and between IL -8 and IGF was showed positive correlationConclusion: Elevated levels of IL-6 and IL-8 predict the development of type 2 DM. These data support a possible role for inflammation in diabetogenesis. Type 2 diabetes as well as pre-diabetic states, including impaired fasting glucose and impaired glucose tolerance, are associated cross-sectionally with altered circulating levels of IGF-I . decline in the levels of IGF-I dependent on duration of diabetes in non insuline dependent diabetic patients