EVALUATION OF HEPATOPROTECTIVE EFFECT OF ETHANOLIC EXTRACT FROM RED BETEL (PIPER CROCATUM RUIZ AND PAV.) LEAVES

Objective: The objective of this study is to identify the effect of red betel (Piper crocatum Ruiz and Pav.) leaves ethanolic extract on hepatoprotective effect on CCl4-induced liver damage in rats.Methods: Standard phytochemical screening method was done for preliminary phytochemical screening. Hepatotoxic rats were induced with CCl4 and treated with ethanolic extract of red betel leaves. The hepatoprotective test was divided into two groups (curative and preventive test). In the curative test, the rats which have been induced with CCl4 were given ethanol extract 600 mg/kg bw each day for 15 days. In the preventive test, the induced rats were given ethanol extract 600 mg/kg bw each day and CCl4 each 4 h for 45 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) parameters were also measured.Result: The phytochemical screening showed an ethanolic extract of red betel leaves which contain a lot of phytochemical compounds. The result of hepatoprotective study showed that the ALT, AST, and ALP registered a significant (p<0.05) alteration in CCl4treated rats.Conclusion: The ethanolic extract of red betel leaves had the curative and preventive test