MEAL INDUCED OXIDATIVE STRESS LEVELS IN CONTROLLED AND POORLY CONTROLLED DIABETES

Objective: The postprandial metabolic derangements are accentuated in type-2 diabetes and are important risk factors for cardiovascular disease since they induce oxidative stress and endothelial dysfunction. Aim of the study was to analyse meal induced oxidative stress levels in controlled and poorly controlled diabetes.Methods: Total 60 type 2 diabetic patients on oral hypoglycemics of duration 5-15 years were divided into two groups based on HbA1c values (£7.5% for controlled /Group-1 and ³7.6% for poorly controlled/ Group-2). They were assayed for serum/plasma glucose, thiobarbituric acid reacting substances (TBARS) and oxidised LDL (ox-LDL) parameters both in fasting and 2 hrs post meal in both the groups. Statistical analysis was done using independent t test between the groups and paired t test within each group.Results: The Postprandial TBARS was found significantly higher in both the groups, whereas no significant difference between the two groups. The ox-LDL levels were found similar at two points of time in both the groups.Conclusion: An exaggerated postprandial oxidative stress levels are associated with diabetes and its complications including endothelial dysfunction. Â