A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS

Objective: To evaluate the efficacy and tolerability of lysine cream in patients with second-degree superficial burns.Methods: In this randomized, open label, comparative study patients with second degree superficial burns received either combination of lysine cream 15% and silver sulfadiazine cream 1% or sulfadiazine cream 1% alone, twice daily for period of 4 weeks. The primary outcome, pain, discharge, size and total body surface area (TBSA) were assessed in each visits.Results: Patients in the study group showed significant change than the control group in pain, discharge, size, and TBSA during the first 4 weeks after treatment. In addition, significantly more patients in lysine group had adequate relief of itching and increased epithelialization.Conclusions: Combination of lysine cream and silver sulfadiazine cream for 4 weeks provided significant relief of pain, discharge, size, TBSA, and itching. Lysine cream was well tolerated.Â