FORMULATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM CONTAINING COMBINATION OF GLIPIZIDE AND METFORMIN HYDROCHLORIDE

The purpose of gastro-retentive drug delivery systems was special focus on the principle mechanism of floatation to achieve gastric retention. The objective is to develop a gastro-retentive drug delivery system of Glipizide and Metformine hydrochloride is to overcome the biggest problem in oral drug delivery is low and erratic drug bioavailability. Glipizide and Metformine hydrochloride are used for the treatment of diabetes mellitus. Seven formulations containing retardant material and alkalizing agent were prepared with solubilizing agent in different ratio. The ability of various polymers to retain the drug when used in different concentrations was investigated. It was found that sodium bicarbonate reacts with HCl and produce CO2 which creates pores in tablet and elevates swelling by wetting polymer. So it helps in maintaining the buoyancy. The release rate could be modified by varying the polymer ratio, concentration of alkalizing and solubilizing agent. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, buoyancy and in vitro dissolution studies