DIPEPTIDYL PEPTIDASE-IV INHIBITORY ACTIVITIES OF MEDICINAL PLANTS: TERMINALIA ARJUNA, COMMIPHORA MUKUL, GYMNEMA SYLVESTRE, MORINDA CITRIFOLIA, EMBLICA OFFICINALIS

Objective: The present study was designed to screen the dipeptidyl peptidase-IV (DPP-IV) inhibitory ability of hydroalcoholic extracts of Terminaliaarjuna, Commiphora mukul, Gymnema sylvestre, Morinda citrifolia, and Emblica officinalis and compare their inhibitory activity with the syntheticDPP-IV inhibitors (Sitagliptin and Vildagliptin). The aim of the study was to identifying indigenous sources of DPP-IV inhibitors for the managementof type II diabetes mellitus as alternatives to their synthetic counterparts.Methods: The hydroalcoholic extract of T. arjuna, C. mukul, G. sylvestre, M. citrifolia, E. officinalis and synthetic DPP-IV inhibitors (Sitagliptin andVildagliptin) were tested in vitro for DPP-IV inhibitory activity.Results: The DPP-IV inhibitory activity of synthetic drugs Vildagliptin was found to be 90.42±7.84% and Sitagliptin 84.67±8.21%. The DPP-IVInhibitory activity of T. arjuna was found to be 83.39±7.58%, C. mukul: 92.97± 8.45%, G. sylvestre: 16.98±1.69%, M. citrifolia: 24.64±2.24%, andE. officinalis: 85.95±7.16%. C. mukul extract showed superior inhibitory activity than reference standard drugs (Sitagliptin and Vildagliptin).Conclusion: C. mukul, T. arjuna, and E. officinalis extracts possess significant DPP-IV Inhibitory activity while G. sylvestre and M. citrifolia failed tomarkedly inhibit DPP-IV enzyme.Keywords: Type II diabetes mellitus, Dipeptidyl peptidase-IV inhibitors, Plant extracts, In vitro assay