ANTI-PYRETIC ACTION OF Caulerpa lentillifera, Hibiscus rosa-sinensis AND Piper sarmentosum AQUEOUS EXTRACT IN MICE

Objective: The present study was conducted to evaluate the anti-pyretic activity of Caulerpa lentillifera, Hibiscus rosa-sinensis, and Piper sarmentosumaqueous extracts.Methods: The suspension of yeast was injected intraperitoneally (0.1 g/kg of bodyweight [BWT]) to induce fever in experimental animals. Rectaltemperature was recorded every hour with a lubricated digital thermometer and animals with at least 0.7°C elevations in body core temperaturewere included in the experiment. The animals with fever were administered orally with aqueous extracts of C. lentillifera, H. rosa-sinensis, andP. sarmentosum (500 mg/kg of BWT). Another group was given the commercial drug, acetaminophen (10 mg/kg of BWT), to serve as a control.Results: The result of the study showed that C. lentillifera and H. rosa-sinensis aqueous extracts significantly (p<0.05) effective in combating fever.However, P. sarmentosum aqueous extract has no potential as an anti-pyretic agent.Conclusion: H. rosa-sinensis and C. lentillifera aqueous extracts have anti-pyretic potential but not P. sarmentosum aqueous extract.Keywords: Caulerpa lentillifera, Hibiscus rosa-sinensis, Piper sarmentosum, Anti-pyretic, Fever, Pyrexia, Yeast