ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFCETS OF THE ETHANOLIC EXTRACT OF ALOCASIA INDICA RHIZOMES IN HIGH FAT DIET/STREPTOZOTOCIN AND STREPTOZOTOCIN/NICOTINAMIDE-INDUCED TYPE 2 DIABETIC RATS

Objective: The investigate the antidiabetic and antihyperlipidemic effect of ethanolic extract of Alocasia indica (EEAI) rhizomes in high-fatdiet/streptozotocin (HFD/STZ) and STZ/nicotinamide-induced Type 2 diabetic rats.Methods: Diabetes was induced in male Wistar rats by the administration of a HFD for 15 days/STZ (35 mg/kg b.w., i.p.) and STZ (60 mg/kg b.w.,i.p.)/nicotinamide (110 mg/kg b.w., i.p.). EEAI (100 and 200 mg/kg b.w., p.o.) was administered to diabetic rats for 28 days in HFD/STZ-inducedType 2 diabetic rats and for 15 days in STZ/nicotinamide-induced Type 2 diabetic rats. The effect of EEAI on blood glucose and body weight wasstudied in Type 2 diabetic rats. All these effects were compared with glibenclamide (5 mg/kg b.w., p.o.) as a reference antidiabetic drug.Results: The administration of the EEAI (100 and 200 mg/kg b.w., p.o.) resulted in a significant decrease in blood glucose level and significant increasein body weight in the HFD/STZ and STZ/nicotinamide-induced Type 2 diabetic rats. Further EEAI showed antihyperlipidemic activity as evidencedby significant decrease in serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very LDL-C levels coupled together withelevation of high-density lipoprotein cholesterol level in diabetic rats in the HFD/STZ and STZ/nicotinamide-induced Type 2 diabetic rats.Conclusion: The results suggest that the EEAI rhizomes possess a promising effect on the HFD/STZ and STZ/nicotinamide-induced Type 2 diabetes.Keywords: Antidiabetic, Antihyperlipidemic, Alocasia indica, High-fat diet, Streptozotocin, Nicotinamide