SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES

Objectives: To synthesize novel pyrazole derivatives and their evaluation for anti-inflammatory activity. Methods: The synthesis of chalcone (1) was carried out by using Claisen-Schmidt condensation. which on further cyclization with thiosemicarbazidegives the substituted 3, 5-diphenyl-4, 5-dihydro-pyrazole-1-carbothoic acid amide (2), further reaction with different aldehydes yield title compounds(3). Using this scheme 8 compounds were synthesized which further have been evaluated for anti-inflammatory activity by egg-albumin induced pawedema.Results: All the synthesized compounds have been supported by spectral analysis. The anti-inflammatory activity of synthesized compounds wascompared with standard anti-inflammatory agent Diclofenac sodium.Conclusion: Compound-8, compound-2 and compound-3 showed greater anti-inflammatory activity due to the presence of alkene and electronwithdrawing groups (Cl and NO2). Keywords: Chalcone, Thiosemicarbazide, Pyrazole derivatives, Anti-inflammatory activity