EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE AERIAL PARTS OF PHYLLANTHUS RETICULATES AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS

ABSTRACTObjective: The present study deals with evaluation of hepatoprotective effect against paracetamol induced hepatitis in rats and in-vitro antioxidantactivity of aerial parts of ethanolic extract (70%) of Phyllanthus reticulates.Methods: Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and total Bilirubin were tested in both treated anduntreated groups.Results: Treatment with ethanolic extract of Phyllanthus reticulates (400 mg/kg) has brought back the altered levels of biochemical markers to thenear normal level which is comparable with the standard drug Silymarin.Conclusion: Further the in-vitro antioxidant activity and total phenolic content showed significant result which in turn encourages further evaluationof this plant in future.Keywords: Phyllanthus, Hepatitis, Biochemical markers, Antioxidant activity, Total phenolic content