ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF IMPORTANT MEDICINAL PLANT PONGAMIA PINNATA (FAMILY: LEGUMINOSEAE)

objectives: A lot of herbal plants and polyherbal formulations are used for the treatment of liver diseases. Methods: This present investigationwas aimed to assess the hepatoprotective activity of aqueous and ethanol extract of Pongamia pinnata leaves against acetaminophen-induced liverdamage in albino rats. Silymarin as a standard drug for comparing the activity. The activity was assessed by comparing the biochemical parametersin serum levels such as serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, total bilirubin, alkaline phosphatase ofplant extracts treated group with acetaminophen treated animals. Results: Results showed, ethanolic extract treated group showed highly significantactivity (p<0.001), whereas aqueous extract treated group has shown the significant (p<0.01) action but less compared with ethanolic extract. Plantextracts restores biochemical enzymes and brings down to normal as compared to standard drug silymarin. Conclusion: This results shows andconfirms the significant protective activity against acetaminophen-induced hepatotoxicity.Keywords: Hepatotoxicity, Antioxidant, Acetaminophen, Pongamia pinnata, Herbal plants