ANTIDIABETIC AND INSULIN SENSITIZING EFFECTS OF PADINA PAVONIA AND TURBENARIA ORNATA IN STREPTOZOTOCIN/NICOTINAMIDE DIABETIC RATS

Objective:The current study was designed to investigate the hypoglycemic, hypolipidemic and insulin sensitizing effects of two marine brown algae, Padinapavoniaand Turbenariaornata.Materials and methods:Type 2 diabetes was induced by intraperitoneal injection of 120 mg/kg b.wt. nicotinamide 30 minutes before injection of 50 mg/kg b.wt. streptozotocin. Extracts of both Padinapavoniaand Turbenariaornata were orally and daily administered at a dose level of 100 mg/kg b.wt. for 21 days to diabetic rats. At the end of the experimental period, blood, pancreas and adipose tissue samples were taken for the subsequent studies.Results:Both Padinapavoniaand Turbenariaornata supplementation potentially ameliorated the elevated levels of glucose, AST, LDH and CK-MB and the lowered serum insulin levels of type 2 diabetic rats. Also, the tested algae increased the β-cell number in pancreata of diabetic rats. Both extracts were also found to alleviate the altered lipid profile and serum adiponectin level as well as the insulin resistance indices, HOMA-IR and QUICKI. In addition, both algae significantly upregulated adipose tissue adiponectin mRNA expression.Conclusion: These experimental findings demonstrated that both Padinapavoniaand Turbenariaornata exhibit antidiabetic effects in a rat model of type 2 diabetes by their insulinotropic and insulin sensitizing effects.Key Words: Adiponectin, insulin resistance, brown algae, diabetes