A Randomized Clinical Trial to Evaluate the Efficacy and Safety of α-Keto Amino Acids Supplementation in stage 3 and 4 patients of Chronic Kidney Disease.

ABSTRACTObjective: To evaluate efficacy and safety of α- Keto Amino Acids (KAA) supplementation in stage 3 and 4 patients of Chronic Kidney Disease.Material and Methods: The study was conducted in stage 3 and 4 patients of Chronic Kidney Disease of a tertiary care centre of north India. Patients were randomly divided into two interventional groups. Group I (Control) was given conservative management and placebo while Group II (KAA) given conservative management along with KAA (600 mg, thrice daily) for 12 weeks. Haemogram and renal function tests were done and adverse effects were recorded at 0, 4, 8 and 12 weeks of treatment. Results: Both groups showed gradual improvement in the biochemical parameters as compared to their pre-treated values which was more marked in KAA supplemented group. There was reduction in blood glucose, blood urea, serum creatinine and 24 hour total urine protein (TUP). There was increase in haemoglobin, 24 hour total urine volume (TUV) and glomerular filtration rate (GFR). There was no statistical difference in two groups with respect to side effects (p>0.05).Conclusion: α-Keto amino acids (KAA) supplementation along with conservative management is efficacious and safe in preventing the progression of disease in stage 3 and 4 patients of Chronic Kidney Disease.KEY WORDS: Keto amino acids, Glomerular filtration rate, End stage renal disease